The 186 neuronspecific isoform of neurofascin (NF186) is required for the clustering of voltage gated Na channels at the nodes of Ranvier. The 155 glialspecific isoform (NF155) is required for the proper assembly of paranodal junction, an important site of interactions between the myelin and axon. Early changes in the distribution of NF155 were observed in MS lesions preceding demyelination.44 Maier et al45 showed that the NF155levels were reduced and a 40 NF155fragment increased in plaques, suggesting that NF155 is subject to protein degradation in the lesions.Levels of antibodies to NF155 and NF186 were significantly higher in sera of patients with chronic progressive forms of MS compared to that of patients with other inflammatory neurological diseases.17 In vitro studies showed that antibodies to neurofascin inhibit axonal conduction.The Broncos were all about power the last time they played the Patriots, and that the way they will try to play tonight. Mike Anderson ran for 1,2