Histologically, biliary dilatation was observed at 1 month of age in 100% of outbred Pkhd1del2/del2 mice (Figure 3b) and it worsened with time (Figure 3c so that by 12 months most of the liver was replaced by cysts. At early stages, bile duct proliferation was evident in the portal areas with primitive tortuous bile ducts and reactive stroma. By 6 months progressive portal fibrosis was evident (Figure 3e and g)..Matthews drew a personalfoul penalty in the 49ers 3428 win Sunday after he tackled Kaepernick out of bounds deep in Green Bay territory during the second quarter.A fracas between players from both teams followed on the sideline when Matthews and 49ers left tackle Joe Staley began pushing and shoving.San Francisco wide receiver Anquan Boldin was docked $7,875 for a late hit on Packers cornerback Jarrett Bush in the third quarter, while 49ers linebacker Ahmad Brooks was fined $12,750 for a roughingthepasser call.The biggest fine of the week came Tuesday, when the league annou