Except for rare cells demonstrating one or two relatively weakly labeled aggregates, primary rat astrocytes or neurons cultured under similar conditions remained unlabelled and their microtubule networks appeared unaltered. Incubation with the scrambled NFLSCR peptide did not alter microtubule organization in astrocytes, neurons or glioma cells. White bars, 10 NFL, neurofilament light; SCR, scrambled; TBS, tubulinbinding site..Everybody is welcome to attend and members are reminded to bring their nomination forms with them. Mass for the deceased players of the club will take place on Sunday morning at 10.30am. Best wishes to all the young people in the area who are participating in Scr na ng on Saturday night in Carnew.

We show that a nonclassical PY nuclear localization signal (NLS) in the Cterminus of FUS is necessary for nuclear import. The majority of fALSassociated mutations occur within the NLS and impair nuclear import to a degree that correlates with the age of dis